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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TADALAFIL

TADALAFIL


ATC C02KX52
ATC G04CB51
ATC C02KX54
ATC G04BE08
ATC G04CA54

GENITO
ERECTILE DYSFUNCTION (THERAPEUTIC)
(CGMP)-SPECIFIC PHOSPHODIESTERASE TYPE 5 INHIBITORS
VASOCONSTRICTOR AGENTS
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)

ORAL

Tmax 2 HOUR

VD 63 LITER

PPB 94 PERCENT

Cl 2.5 LITER / HOUR

HT 17.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 5

PDB 1XOZ (CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH TADALAFIL)

LIGAND CODE = CIA (link to the list of PDB complexes)

Download experimental 3D coordinates of CIA with added hydrogens

cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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