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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| QUINIDINE
| QUINIDINE | NATURAL MOLECULE (link)
CARDIOVASCULAR | INJECTION ORAL | Tmax 2 HOUR F 70 PERCENT VD 162.5 LITER (65 KILOGRAM) PPB 84 PERCENT Cl 15.6 LITER / HOUR (65 KILOGRAM) HT 7 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | ADRENERGIC ALPHA-1 RECEPTOR P-GLYCOPROTEIN PDB 4WNU (HUMAN CYTOCHROME P450 2D6 QUINIDINE COMPLEX) LIGAND CODE = QDN (link to the list of PDB complexes) Download experimental 3D coordinates of QDN with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel alpha subunits more at DrugCentral | EMA | |||
