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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MIGLUSTAT

MIGLUSTAT


ATC A16AX06

METABOLISM
TYPE 1 GAUCHER DISEASE
GLUCOSYLCERAMIDE SYNTHASE INHIBITOR
SYNTHESIS OF MOST GLYCOSPHINGOLIPIDS
TREATMENT OF NIEMANN-PICK TYPE C DISEASE (DRUG FOR RARE DISEASE IN EUROPE)

ORAL

Tmax 2.25 HOUR

F 97 PERCENT

VD 94 LITER

PPB 0 PERCENT

Cl 13.8 LITER / HOUR

HT 6.5 HOUR

SOLUBILITY HIGHLY SOLUBLE IN WATER (> 1000 MILLIGRAM / MILLILITER)

GLUCOSYLCERAMIDE SYNTHASE

PDB 2V3D (ACID-BETA-GLUCOSIDASE WITH N-BUTYL-DEOXYNOJIRIMYCIN)

LIGAND CODE = NBV (link to the list of PDB complexes)

Download experimental 3D coordinates of NBV with added hydrogens

CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR CHEMBL2063 CERAMIDE GLUCOSYLTRANSFERASE Q16739 CERAMIDE GLUCOSYLTRANSFERASE HOMO SAPIENS ENZYME TRANSFERASEANSM (in French)

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