| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FONDAPARINUX
| FONDAPARINUX | BLOOD | SUBCUTANEOUS | Cmax 0.22 MICROMOLAR Tmax 2 HOUR F 100 PERCENT VD 9 LITER PPB 0 PERCENT Cl 0.32 LITER / HOUR (EQN) HT 19 HOUR | ANTITHROMBIN-III PDB 4X7R (CRYSTAL STRUCTURE OF S. AUREUS TARM G117R MUTANT IN COMPLEX WITH FONDAPARINUX, ALPHA-GLCNAC-GLYCEROL AND UDP) LIGAND CODE = NTO (link to the list of PDB complexes) Download experimental 3D coordinates of NTO with added hydrogens | Antithrombin-III UNIPROT P01008 SERPINC1 more at DrugCentral | EMA | |||
