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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FULVESTRANT

FULVESTRANT


ATC L02BA03

ANTINEOPLASTIC
BREAST CANCER (THERAPEUTIC)
ANTIESTROGENIC
ESTROGEN ANTAGONISTS
TREATMENT OF HORMONE RECEPTOR POSITIVE METASTATIC BREAST CANCER

INTRAMUSCULAR

Cmax 46.2 NANOMOLAR

VD 260 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 41.4 LITER / HOUR

HT 960 HOUR

ESTROGEN RECEPTOR

PDB 4J03 (CRYSTAL STRUCTURE OF HUMAN SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH FULVESTRANT)

LIGAND CODE = FVS (link to the list of PDB complexes)

Download experimental 3D coordinates of FVS with added hydrogens

ESTROGEN RECEPTOR ANTAGONIST CHEMBL2093866 ESTROGEN RECEPTOR P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1ANSM (in French)

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