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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DUTASTERIDE

DUTASTERIDE


ATC G04CB02
ATC G04CA52

GENITO
5-ALPHA-REDUCTASE INHIBITOR
TREATMENT OF SYMPTOMATIC BENIGN PROSTATIC HYPERPLASIA (BPH)

ORAL

Cmax 6.4 NANOMOLAR

Tmax 2.5 HOUR

F 60 PERCENT

VD 400 LITER

PPB 99 PERCENT

Cl 0.33 LITER / HOUR (EQN)

HT 840 HOUR

SOLUBILITY INSOLUBLE IN WATER

5 ALPHA-REDUCTASE

STEROID 5-ALPHA-REDUCTASE INHIBITOR CHEMBL2363075 STEROID 5-ALPHA-REDUCTASE P18405 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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