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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DUTASTERIDE

DUTASTERIDE


ATC G04CB02
ATC G04CA52

GENITO
5-ALPHA-REDUCTASE INHIBITOR
TREATMENT OF SYMPTOMATIC BENIGN PROSTATIC HYPERPLASIA (BPH)

ORAL

Cmax 6.4 NANOMOLAR

Tmax 2.5 HOUR

F 60 PERCENT

VD 400 LITER

PPB 99 PERCENT

Cl 0.33 LITER / HOUR (EQN)

HT 840 HOUR

SOLUBILITY INSOLUBLE IN WATER

5 ALPHA-REDUCTASE

3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT P31213 SRD5A2 -- 3-oxo-5-alpha-steroid 4-dehydrogenase 1 UNIPROT P18405 SRD5A1

more at DrugCentral

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