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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
METHIMAZOLE

METHIMAZOLE


ATC H03BB02
ATC H03BB52

HORMONES
TREATMENT OF HYPERTHYROIDISM
INHIBITS THE SYNTHESIS OF THYROID HORMONES

ORAL

Cmax 1.3 MICROMOLAR (10 MILLIGRAM , PMID6642787)

Tmax 0.9 HOUR

VD 136 LITER (65 KILOGRAM , PMID3830069)

Cl 4.6 LITER / HOUR (65 KILOGRAM)

HT 5.4 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

PDB 2GVC (CRYSTAL STRUCTURE OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)FROM S.POMBE AND SUBSTRATE (METHIMAZOLE) COMPLEX)

LIGAND CODE = MMZ (link to the list of PDB complexes)

Download experimental 3D coordinates of MMZ with added hydrogens

THYROID PEROXIDASE INHIBITOR CHEMBL1839 THYROID PEROXIDASE P07202 THYROID PEROXIDASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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