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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BIMATOPROST

BIMATOPROST


ATC S01EE03

SENSORY
ANTIHYPERTENSIVE
ANTIGLAUCOMA
PROSTAGLANDIN ANALOG

OPHTHALMIC TOPICAL

Cmax 0.19 NANOMOLAR

Tmax 0.16 HOUR

VD 43.5 LITER (65 KILOGRAM)

PPB 12 PERCENT

Cl 97.5 LITER / HOUR (65 KILOGRAM)

HT 0.75 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

PDB 2F38 (CRYSTAL STRUCTURE OF PROSTAGLANDIN F SYNATHASE CONTAINING BIMATOPROST)

LIGAND CODE = 15M (link to the list of PDB complexes)

Download experimental 3D coordinates of 15M with added hydrogens

PROSTANOID FP RECEPTOR AGONIST CHEMBL1987 PROSTANOID FP RECEPTOR P43088 PROSTAGLANDIN F2-ALPHA RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR PROSTANOID RECEPTORANSM (in French)

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