Cheminformatic Tools and Databases for Pharmacology

session 57558 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TREPROSTINIL

TREPROSTINIL


ATC B01AC21

BLOOD
ANTIHYPERTENSIVE AGENTS
ANTITHROMBOTIC AGENTS
PROSTACYCLIN ANALOGS
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)
PROSTACYCLIN (IP) RECEPTOR AGONIST

IV SUBCUTANEOUS INHALATION ORAL INTRAVENOUS

Cmax 3.4 NANOMOLAR

Tmax 0.12 HOUR

F 72 PERCENT

VD 13 LITER (65 KILOGRAM)

PPB 91 PERCENT

Cl 27.8 LITER / HOUR (65 KILOGRAM)

HT 4 HOUR

PROSTACYCLIN RECEPTOR

PDB 8X7A (TREPROSTINIL BOUND PROSTACYCLIN RECEPTOR G PROTEIN COMPLEX)

LIGAND CODE = Y9J (link to the list of PDB complexes)

Download experimental 3D coordinates of Y9J with added hydrogens

Prostacyclin receptor UNIPROT P43119 PTGIR

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |