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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TREPROSTINIL

TREPROSTINIL


ATC B01AC21

BLOOD
ANTIHYPERTENSIVE AGENTS
ANTITHROMBOTIC AGENTS
PROSTACYCLIN ANALOGS
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)
PROSTACYCLIN (IP) RECEPTOR AGONIST

IV SUBCUTANEOUS INHALATION ORAL INTRAVENOUS

Cmax 5.12 NANOMOLAR

Tmax 10 HOUR

F 100 PERCENT

VD 13 LITER (65 KILOGRAM)

PPB 91 PERCENT

Cl 27.8 LITER / HOUR (65 KILOGRAM)

HT 4 HOUR

PROSTACYCLIN RECEPTOR

PROSTANOID IP RECEPTOR AGONIST CHEMBL1995 PROSTANOID IP RECEPTOR P43119 PROSTACYCLIN RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR PROSTANOID RECEPTORANSM (in French)

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