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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VORICONAZOLE
| VORICONAZOLE | ANTIINFECTIVES | ORAL INTRAVENOUS INJECTION IV | Cmax 13.4 MICROMOLAR Tmax 1.5 HOUR F 96 PERCENT VD 299 LITER (65 KILOGRAM) PPB 58 PERCENT Cl 32.3 LITER / HOUR (65 KILOGRAM) HT 5.6 HOUR | CYTOCHROME P450 CYP51 PDB 5HS1 (SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) COMPLEXED WITH VORICONAZOLE) LIGAND CODE = VOR (link to the list of PDB complexes) Download experimental 3D coordinates of VOR with added hydrogens | Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 more at DrugCentral | EMA | |||
