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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VORICONAZOLE

VORICONAZOLE


ATC J02AC03

ANTIINFECTIVES
ANTIFUNGAL
INHIBITION OF FUNGAL CYTOCHROME P-450-MEDIATED 14 ALPHA-LANOSTEROL DEMETHYLATION (CYP51) AN ESSENTIAL STEP IN FUNGAL ERGOSTEROL BIOSYNTHESIS

ORAL INTRAVENOUS INJECTION IV

Cmax 13.4 MICROMOLAR

Tmax 1.5 HOUR

F 96 PERCENT

VD 299 LITER (65 KILOGRAM)

PPB 58 PERCENT

Cl 32.3 LITER / HOUR (65 KILOGRAM)

HT 5.6 HOUR

CYTOCHROME P450 CYP51

PDB 5HS1 (SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) COMPLEXED WITH VORICONAZOLE)

LIGAND CODE = VOR (link to the list of PDB complexes)

Download experimental 3D coordinates of VOR with added hydrogens

CYTOCHROME P450 51 INHIBITOR CHEMBL1780 CYTOCHROME P450 51 P10613 LANOSTEROL 14-ALPHA DEMETHYLASE CANDIDA ALBICANS (STRAIN SC5314 / ATCC MYA-2876) (YEAST) ENZYME CYTOCHROME P450 CYP_51 CYP_51A CYP_51A1ANSM (in French)

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