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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
APOMORPHINE

APOMORPHINE


ATC G04BE07
ATC N04BC07

NERVOUS SYSTEM
ANTIDYSKINETICS
ANTIPARKINSON AGENTS
NON-ERGOLINE DOPAMINE AGONIST D4 (KI = 4.4 NANOMOLAR) D2 (KI = 35 NANOMOLAR) D3 (KI = 26 NANOMOLAR) D5 (KI = 15 NANOMOLAR)

SUBCUTANEOUS SUBLINGUAL

F 100 PERCENT

VD 218 LITER

PPB 94 PERCENT

Cl 223 LITER / HOUR

HT 0.66 HOUR

SOLUBILITY SOLUBLE IN WATER

DOPAMINE D2 RECEPTOR

PDB 7JVQ (CRYO-EM STRUCTURE OF APOMORPHINE-BOUND DOPAMINE RECEPTOR 1 IN COMPLEX WITH GS PROTEIN)

LIGAND CODE = OR9 (link to the list of PDB complexes)

Download experimental 3D coordinates of OR9 with added hydrogens

ALPHA-2A ADRENERGIC RECEPTOR P08913 ALPHA-2A ADRENERGIC RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR ADRENERGIC RECEPTORANSM (in French)

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