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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| APOMORPHINE
| APOMORPHINE | NERVOUS SYSTEM | SUBCUTANEOUS SUBLINGUAL | F 100 PERCENT VD 218 LITER PPB 94 PERCENT Cl 223 LITER / HOUR HT 0.66 HOUR SOLUBILITY SOLUBLE IN WATER | DOPAMINE D2 RECEPTOR PDB 7JVQ (CRYO-EM STRUCTURE OF APOMORPHINE-BOUND DOPAMINE RECEPTOR 1 IN COMPLEX WITH GS PROTEIN) LIGAND CODE = OR9 (link to the list of PDB complexes) Download experimental 3D coordinates of OR9 with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 more at DrugCentral | EMA | |||
