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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NITISINONE

NITISINONE


ATC A16AX04

METABOLISM
HEREDITARY TYROSINEMIA TYPE 1
INHIBITOR OF 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE
TREATMENT OF HEREDITARY TYROSINEMIA TYPE 1 (HT-1)

ORAL

Tmax 3 HOUR

F 90 PERCENT

Cl 0.26 LITER / HOUR (65 KILOGRAM)

HT 54 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE INHIBITOR CHEMBL1861 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE P32754 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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