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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TEGASEROD DISCONTINUED

TEGASEROD


ATC A03AE02
ATC A06AX06

METABOLISM
PERISTALTIC STIMULANT
IRRITABLE BOWEL SYNDROME (THERAPEUTIC)
SEROTONIN AGONISTS
5-HT4 RECEPTOR PARTIAL AGONIST

ORAL

Tmax 1 HOUR

F 10 PERCENT

VD 368 LITER

PPB 98 PERCENT

Cl 77 LITER / HOUR

HT 11 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

5-HYDROXYTRYPTAMINE 4 RECEPTOR

SEROTONIN 4 (5-HT4) RECEPTOR PARTIAL AGONIST CHEMBL1875 SEROTONIN 4 (5-HT4) RECEPTOR Q13639 5-HYDROXYTRYPTAMINE RECEPTOR 4 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR SEROTONIN RECEPTORANSM (in French)

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