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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TELITHROMYCIN DISCONTINUED

TELITHROMYCIN


ATC J01FA15

ANTIINFECTIVES
ANTIBIOTIC
ANTI-BACTERIAL AGENTS
KETOLIDE
BINDING TO DOMAINS II AND V OF 23S RRNA OF THE 50S RIBOSOMAL SUBUNIT

ORAL

Cmax 2.46 MICROMOLAR

Tmax 1 HOUR

F 57 PERCENT

VD 188 LITER

PPB 65 PERCENT

Cl 54.6 LITER / HOUR (65 KILOGRAM)

HT 10 HOUR

50S RIBOSOMAL SUBUNIT

PDB 4V7Z (STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH TELITHROMYCIN.)

LIGAND CODE = TEL (link to the list of PDB complexes)

Download experimental 3D coordinates of TEL with added hydrogens

BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIAANSM (in French)

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SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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