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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LEVOTHYROXINE
| LEVOTHYROXINE | HORMONES | ORAL INTRAVENOUS | F 94 PERCENT PPB 99 PERCENT HT 156 HOUR | THYROID HORMONE RECEPTOR PDB 4X30 (CRYSTAL STRUCTURE OF HUMAN THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROINE AT 1.55 ANGSTROM RESOLUTION) LIGAND CODE = T44_4X30 (link to the list of PDB complexes) Download experimental 3D coordinates of T44_4X30 with added hydrogens | Thyroid hormone receptor alpha UNIPROT P10827 THRA -- Thyroid hormone receptor beta UNIPROT P10828 THRB more at DrugCentral | EMA | |||
