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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LEVOTHYROXINE

LEVOTHYROXINE


ATC H03AA01

HORMONES
THYROMIMETIC
ANTICOAGULANTS
SYNTHETIC L-THYROXINE T4
ANTITHYROID AGENTS
HYPOTHYROIDISM

ORAL INTRAVENOUS

F 94 PERCENT

PPB 99 PERCENT

HT 156 HOUR

THYROID HORMONE RECEPTOR

PDB 4X30 (CRYSTAL STRUCTURE OF HUMAN THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROINE AT 1.55 ANGSTROM RESOLUTION)

LIGAND CODE = T44_4X30 (link to the list of PDB complexes)

Download experimental 3D coordinates of T44_4X30 with added hydrogens

THYROID HORMONE RECEPTOR AGONIST CHEMBL2111462 THYROID HORMONE RECEPTOR P10827 THYROID HORMONE RECEPTOR ALPHA HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR1 NR1A NR1A1ANSM (in French)

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