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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MOXIFLOXACIN
| MOXIFLOXACIN | ANTIINFECTIVE | ORAL INTRAVENOUS OPHTHALMIC | Cmax 10.8 MICROMOLAR Tmax 2 HOUR F 90 PERCENT VD 143 LITER (65 KILOGRAM) PPB 40 PERCENT Cl 12 LITER / HOUR HT 12.7 HOUR | TOPOISOMERASE II (DNA GYRASE) TOPOISOMERASE 4 PDB 5CDQ (2.95A STRUCTURE OF MOXIFLOXACIN WITH S.AUREUS DNA GYRASE AND DNA) LIGAND CODE = MFX (link to the list of PDB complexes) Download experimental 3D coordinates of MFX with added hydrogens | Topoisomerase IV UNIPROT P0AFI2 parC -- DNA gyrase UNIPROT P0AES4 gyrA more at DrugCentral | EMA | |||
