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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SIROLIMUS (is an active metabolite)
| SIROLIMUS | NATURAL MOLECULE (link)
ANTINEOPLASTIC | ORAL INTRAVENOUS TOPICAL | Cmax 15.7 NANOMOLAR Tmax 2.1 HOUR F 14 PERCENT VD 780 LITER (65 KILOGRAM) PPB 92 PERCENT Cl 11.2 LITER / HOUR (65 KILOGRAM) HT 62 HOUR SOLUBILITY INSOLUBLE IN WATER | FK BINDING PROTEIN-12 (FKBP-12) PDB 5HKG (TOTAL CHEMICAL SYNTHESIS, REFOLDING AND CRYSTALLOGRAPHIC STRUCTURE OF A FULLY ACTIVE IMMUNOPHILIN: CALSTABIN 2 (FKBP12.6).) LIGAND CODE = RAP (link to the list of PDB complexes) Download experimental 3D coordinates of RAP with added hydrogens | Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TEMSIROLIMUS (has an active metabolite)
| TEMSIROLIMUS | ANTINEOPLASTIC AGENTS | INTRAVENOUS | Cmax 056 MICROMOLAR (25 MILLIGRAM) VD 172 LITER Cl 16.2 LITER / HOUR HT 17.3 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | FK506 BINDING PROTEIN-12 (FKBP-12)/MTOR COMPLEX PDB 7SQ9 (CRYO-EM STRUCTURE OF MOUSE TEMSIROLIMUS, PI(3,5)P2-BOUND TRPML1 CHANNEL AT 2.11 ANGSTROM RESOLUTION) LIGAND CODE = A4I (link to the list of PDB complexes) Download experimental 3D coordinates of A4I with added hydrogens | Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A more at DrugCentral | EMA | |||
