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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SIROLIMUS (is an active metabolite)
| SIROLIMUS | NATURAL MOLECULE (link) ANTINEOPLASTIC | ORAL INTRAVENOUS TOPICAL | Cmax 15.7 NANOMOLAR Tmax 2.1 HOUR F 14 PERCENT VD 780 LITER (65 KILOGRAM) PPB 92 PERCENT Cl 11.2 LITER / HOUR (65 KILOGRAM) HT 62 HOUR SOLUBILITY INSOLUBLE IN WATER | FK BINDING PROTEIN-12 (FKBP-12) PDB 5HKG (TOTAL CHEMICAL SYNTHESIS, REFOLDING AND CRYSTALLOGRAPHIC STRUCTURE OF A FULLY ACTIVE IMMUNOPHILIN: CALSTABIN 2 (FKBP12.6).) LIGAND CODE = RAP (link to the list of PDB complexes) Download experimental 3D coordinates of RAP with added hydrogens | FK506-BINDING PROTEIN 1A INHIBITOR CHEMBL1902 FK506-BINDING PROTEIN 1A P62942 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A HOMO SAPIENS ENZYME ISOMERASE | ANSM (in French) | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TEMSIROLIMUS (has an active metabolite)
| TEMSIROLIMUS | ANTINEOPLASTIC AGENTS | INTRAVENOUS | Cmax 056 MICROMOLAR (25 MILLIGRAM) VD 172 LITER Cl 16.2 LITER / HOUR HT 17.3 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | FK506 BINDING PROTEIN-12 (FKBP-12)/MTOR COMPLEX | FK506-BINDING PROTEIN 1A INHIBITOR CHEMBL1902 FK506-BINDING PROTEIN 1A P62942 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A HOMO SAPIENS ENZYME ISOMERASE | ANSM (in French) | |||
