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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BEXAROTENE

BEXAROTENE


ATC L01XX25

ANTILEOPLASTIC
RETINOID RECEPTOR RXRS AGONIST
ANTINEOPLASTIC
ANTICANCER
ANTICARCINOGENIC AGENTS

ORAL TOPICAL

Cmax 158 NANOMOLAR

Tmax 2 HOUR

PPB 99 PERCENT

HT 7 HOUR

SOLUBILITY INSOLUBLE IN WATER

RETINOIC ACID RECEPTOR RXR ALPHA
RETINOIC ACID RECEPTOR RXR BETA
RETINOIC ACID RECEPTOR RXR GAMMA

PDB 4K6I (CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH TARGRETIN AND THE COACTIVATOR PEPTIDE GRIP-1)

LIGAND CODE = 9RA (link to the list of PDB complexes)

Download experimental 3D coordinates of 9RA with added hydrogens

RETINOID X RECEPTOR AGONIST CHEMBL2363070 RETINOID X RECEPTOR P19793 RETINOIC ACID RECEPTOR RXR-ALPHA HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR2 NR2B NR2B1ANSM (in French)

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