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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BEXAROTENE
| BEXAROTENE | ANTILEOPLASTIC | ORAL TOPICAL | Cmax 158 NANOMOLAR Tmax 2 HOUR PPB 99 PERCENT HT 7 HOUR SOLUBILITY INSOLUBLE IN WATER | RETINOIC ACID RECEPTOR RXR ALPHA RETINOIC ACID RECEPTOR RXR BETA RETINOIC ACID RECEPTOR RXR GAMMA PDB 4K6I (CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH TARGRETIN AND THE COACTIVATOR PEPTIDE GRIP-1) LIGAND CODE = 9RA (link to the list of PDB complexes) Download experimental 3D coordinates of 9RA with added hydrogens | Retinoic acid receptor RXR-alpha UNIPROT P19793 RXRA -- Retinoic acid receptor RXR-beta UNIPROT P28702 RXRB more at DrugCentral | EMA | |||
