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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ROFECOXIB DISCONTINUED
| ROFECOXIB | MUSCULO-SKELETAL SYSTEM | ORAL | Cmax 1.02 MICROMOLAR Tmax 2.5 HOUR F 93 PERCENT VD 91 LITER PPB 87 PERCENT Cl 8.46 LITER / HOUR HT 17 HOUR SOLUBILITY INSOLUBLE IN WATER | PROSTAGLANDIN G/H SYNTHASE 2 (COX-2) PDB 5KIR (THE STRUCTURE OF VIOXX BOUND TO HUMAN COX-2) LIGAND CODE = RCX (link to the list of PDB complexes) Download experimental 3D coordinates of RCX with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 more at DrugCentral | EMA | |||
