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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZANAMIVIR
| ZANAMIVIR | ANTIINFECTIVES | INHALATION | Cmax 427.7 NANOMOLAR Tmax 1.5 HOUR F 10.5 PERCENT VD 14.9 LITER (65 KILOGRAM) PPB 10 PERCENT Cl 6.7 LITER / HOUR HT 3.8 HOUR SOLUBILITY 18 MILLIGRAM / MILLILITER IN WATER | NEURAMINIDASE PDB 3TIC (CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR) LIGAND CODE = ZMR (link to the list of PDB complexes) Download experimental 3D coordinates of ZMR with added hydrogens | Neuraminidase UNIPROT P03468 -- Neuraminidase UNIPROT P03474 more at DrugCentral | EMA | |||
