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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ZANAMIVIR

ZANAMIVIR


ATC J05AH01

ANTIINFECTIVES
ANTIVIRAL
ANTIINFLUENZA
NEURAMINIDASE INHIBITOR

INHALATION

Cmax 427.7 NANOMOLAR

Tmax 1.5 HOUR

F 10.5 PERCENT

VD 14.9 LITER (65 KILOGRAM)

PPB 10 PERCENT

Cl 6.7 LITER / HOUR

HT 3.8 HOUR

SOLUBILITY 18 MILLIGRAM / MILLILITER IN WATER

NEURAMINIDASE

PDB 3TIC (CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR)

LIGAND CODE = ZMR (link to the list of PDB complexes)

Download experimental 3D coordinates of ZMR with added hydrogens

NEURAMINIDASE INHIBITOR CHEMBL2051 NEURAMINIDASE P03468 NEURAMINIDASE INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1)) ENZYME HYDROLASEANSM (in French)

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