| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CYCLOSPORINE
| CYCLOSPORINE | NATURAL MOLECULE (link) IMMUNOMODULATORY AGENT | OPHTHALMIC INJECTION ORAL | Cmax 224 NANOMOLAR Tmax 3.5 HOUR F 30 PERCENT VD 214 LITER PPB 90 PERCENT Cl 29.2 LITER / HOUR HT 19 HOUR | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (CYCLOPHILIN) PDB 2WFJ (ATOMIC RESOLUTION CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF HUMAN CYCLOPHILIN G IN COMPLEX WITH CYCLOSPORIN A) LIGAND CODE = CYCLOSPORINEA (link to the list of PDB complexes) Download experimental 3D coordinates of CYCLOSPORINEA with added hydrogens | Peptidyl-prolyl cis-trans isomerase A UNIPROT P62937 PPIA more at DrugCentral | EMA | |||
