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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
REPAGLINIDE

REPAGLINIDE


ATC A10BX02
ATC A10BD14

METABOLISM
ANTIDIABETIC
HYPOGLYCEMIC AGENTS
MEGLITINIDE
MANAGEMENT OF TYPE 2 DIABETES MELLITUS

ORAL

Cmax 145.5 NANOMOLAR

Tmax 1 HOUR

F 56 PERCENT

VD 31 LITER

PPB 98 PERCENT

Cl 38 LITER / HOUR

HT 1 HOUR

ATP DEPENDANT POTASSIUM CHANNEL

PDB 6JB3 (STRUCTURE OF SUR1 SUBUNIT BOUND WITH REPAGLINIDE)

LIGAND CODE = BJX (link to the list of PDB complexes)

Download experimental 3D coordinates of BJX with added hydrogens

SULFONYLUREA RECEPTOR 1, Q09428 ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 HOMO SAPIENS TRANSPORTER NTPASE ATP BINDING CASSETTE MRPANSM (in French)

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