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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LETROZOLE

LETROZOLE


ATC L02BG04

ANTINEOPLASTIC
AROMATASE INHIBITORS
TREATMENT OF POSTMENOPAUSAL WOMEN WITH EARLY BREAST CANCER (INHIBITOR OF ESTROGEN SYNTHESIS)

ORAL

VD 123.5 LITER (65 KILOGRAM)

PPB 39 PERCENT

Cl 2.22 LITER / HOUR (65 KILOGRAM)

HT 48 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

CYTOCHROME P450 19 (AROMATASE)

CYTOCHROME P450 19A1 INHIBITOR CHEMBL1978 CYTOCHROME P450 19A1 P11511 AROMATASE HOMO SAPIENS ENZYME CYTOCHROME P450 CYP_19 CYP_19A CYP_19A1ANSM (in French)

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