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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ATORVASTATIN

ATORVASTATIN


ATC C10AA05
ATC C10BX03
ATC C10BA05
ATC C10BX08
ATC C10BX06
ATC C10BX11
ATC C10BX12
ATC C10BX15
ATC C10BA08

CARDIOVASCULAR
ANTIHYPERLIPIDEMIC
HMG-COA REDUCTASE INHIBITOR
ANTICHOLESTEREMIC AGENTS

ORAL

Tmax 1.5 HOUR

F 14 PERCENT

VD 381 LITER

PPB 98 PERCENT

Cl 18.8 LITER / HOUR (EQN)

HT 14 HOUR

SOLUBILITY IS VERY SLIGHTLY SOLUBLE IN DISTILLED WATER PH 7.4 PHOSPHATE BUFFER

3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE

PDB 1HWK (COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN)

LIGAND CODE = 117 (link to the list of PDB complexes)

Download experimental 3D coordinates of 117 with added hydrogens

HMG-COA REDUCTASE INHIBITOR CHEMBL402 HMG-COA REDUCTASE P04035 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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