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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TOLCAPONE

TOLCAPONE


ATC N04BX01

NERVOUS SYSTEM
ANTIPARKINSONIAN
ANTIDYSKINETICS
CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITOR
DRUG IS METHYLATED BY COMT TO 3-O-METHYL-TOLCAPON

ORAL

Cmax 21.9 MICROMOLAR

Tmax 2 HOUR

F 65 PERCENT

VD 9 LITER

PPB 99.9 PERCENT

Cl 7 LITER / HOUR

HT 2.5 HOUR

CATECHOL O-METHYLTRANSFERASE

PDB 5A6I (V122I TRANSTHYRETIN STRUCTURE IN COMPLEX WITH TOLCALPONE)

LIGAND CODE = TCW (link to the list of PDB complexes)

Download experimental 3D coordinates of TCW with added hydrogens

CATECHOL O-METHYLTRANSFERASE INHIBITOR CHEMBL2023 CATECHOL O-METHYLTRANSFERASE P21964 CATECHOL O-METHYLTRANSFERASE HOMO SAPIENS ENZYME TRANSFERASEANSM (in French)

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