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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DONEPEZIL

DONEPEZIL


ATC N06DA02
ATC N06DA52
ATC N06DA53

NERVOUS SYSTEM
ACETYLCHOLINESTERASE INHIBITOR (REVERSIBLE)
COGNITIVE ENHANCER
ANTI-ALZHEIMER'S DISEASE
CHOLINESTERASE INHIBITORS
INCREASES CONCENTRATION OF ACETYLCHOLINE

ORAL TRANSDERMAL

Cmax 160 NANOMOLAR (PMID18621671)

Tmax 3 HOUR

VD 910 LITER (65 KILOGRAM)

PPB 96 PERCENT

Cl 8.4 LITER / HOUR (65 KILOGRAM)

HT 70 HOUR

SOLUBILITY SOLUBLE IN WATER

ACETYLCHOLINESTERASE

ACETYLCHOLINESTERASE INHIBITOR CHEMBL220 ACETYLCHOLINESTERASE P22303 ACETYLCHOLINESTERASE HOMO SAPIENS ENZYME HYDROLASEANSM (in French)

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