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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MIGLITOL

MIGLITOL


ATC A10BF02

METABOLISM
ANTIDIABETIC
HYPOGLYCEMIC AGENTS
MEMBRANE-BOUND INTESTINAL ALPHA-GLUCOSIDE HYDROLASE INHIBITOR
MANAGEMENT OF ON-INSULIN-DEPENDENT DIABETES MELLITUS (NIDDM)

ORAL

Tmax 2.5 HOUR

VD 11.7 LITER (65 KILOGRAM)

PPB 4 PERCENT

Cl 6.6 LITER / HOUR (65 KILOGRAM)

HT 2 HOUR

SOLUBILITY SOLUBLE IN WATER

ALPHA-GLUCOSIDASE

PDB 5NN6 (CRYSTAL STRUCTURE OF HUMAN LYSOSOMAL ACID-ALPHA-GLUCOSIDASE, GAA, IN COMPLEX WITH N-HYDROXYETHYL-1-DEOXYNOJIRIMYCIN)

LIGAND CODE = MIG (link to the list of PDB complexes)

Download experimental 3D coordinates of MIG with added hydrogens

MALTASE-GLUCOAMYLASE INHIBITOR CHEMBL2074 MALTASE-GLUCOAMYLASE O43451 MALTASE-GLUCOAMYLASE, INTESTINAL HOMO SAPIENS ENZYME HYDROLASEANSM (in French)

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