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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TOPOTECAN
| TOPOTECAN | ANTINEOPLASTIC | INJECTION ORAL INTRAVENOUS | Tmax 1.5 HOUR F 40 PERCENT VD 117 LITER (65 KILOGRAM) PPB 35 PERCENT Cl 50.7 LITER / HOUR HT 2.5 HOUR SOLUBILITY SOLUBLE IN WATER | TOPOISOMERASE I PDB 1RRJ (STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I) LIGAND CODE = TTC (link to the list of PDB complexes) Download experimental 3D coordinates of TTC with added hydrogens | DNA topoisomerase I, mitochondrial UNIPROT Q969P6 TOP1MT more at DrugCentral | EMA | |||
