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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TIAGABINE
| TIAGABINE | NERVOUS SYSTEM | ORAL | Tmax 0.75 HOUR F 90 PERCENT VD 71.5 LITER (65 KILOGRAM) PPB 96 PERCENT Cl 6.5 LITER / HOUR HT 8 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | GAMMA AMINOBUTYRIC ACID (GABA) UPTAKE CARRIER PDB 7Y7Z (CRYO-EM STRUCTURE OF HUMAN GABA TRANSPORTER GAT1 BOUND WITH TIAGABINE IN NACL SOLUTION IN AN INWARD-OPEN STATE AT 3.2 ANGSTROM) LIGAND CODE = TGI (link to the list of PDB complexes) Download experimental 3D coordinates of TGI with added hydrogens | Sodium- and chloride-dependent GABA transporter 1 UNIPROT P30531 SLC6A1 more at DrugCentral | EMA | |||
