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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMINOSALICYLIC ACID (is an active metabolite)
| AMINOSALICYLIC ACID AMINOSALICYLATE | ANTIINFECTIVES | ORAL | Cmax 130.7 MICROMOLAR Tmax 6 HOUR VD 51.8 LITER PPB 55 PERCENT Cl 9.42 LITER / HOUR (PMID25114132) HT 3.25 HOUR | DIHYDROFOLATE REDUCTASE (DHFR) (PMID26848874) PDB 5X7Z (CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH P-AMINOSALICYLIC ACID) LIGAND CODE = BHA (link to the list of PDB complexes) Download experimental 3D coordinates of BHA with added hydrogens | Cyclooxygenase UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PHENYL AMINOSALICYLATE DISCONTINUED (has an active metabolite)
| PHENYL AMINOSALICYLATE | ANTIINFECTIVES | ORAL | DIHYDROFOLATE REDUCTASE (DHFR) (PMID26848874) | Cyclooxygenase UNIPROT P23219 PTGS1 more at DrugCentral | EMA | ||||
