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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SIBUTRAMINE DISCONTINUED (has an active metabolite)
| SIBUTRAMINE | METABOLISM | ORAL | Tmax 1.2 HOUR PPB 97 PERCENT Cl 1750 LITER / HOUR HT 1.1 HOUR SOLUBILITY 2.9 MILLIGRAM / MILLILITER IN PH 5.2 | MONOAMINE REUPTAKE | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
