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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RILUZOLE

RILUZOLE


ATC N07XX02

NERVOUS SYSTEM
NEUROPROTECTIVE
INHIBITORY EFFECT ON GLUTAMATE RELEASE
PARTIAL INACTIVATION OF VOLTAGE-DEPENDENT SODIUM CHANNELS (PMID25548669)
SEDATIVES
MYORELAXANT
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
ACTIVATES SK CHANNELS BUT NOT BK CHANNELS

ORAL

Cmax 739 NANOMOLAR

F 60 PERCENT

VD 245 LITER

PPB 96 PERCENT

HT 12 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS (PMID26311432)

PDB 5V02 (A POSITIVE ALLOSTERIC MODULATOR BINDING POCKET IN SK2 ION CHANNELS IS SHARED BY RILUZOLE AND CYPPA)

LIGAND CODE = 657 (link to the list of PDB complexes)

Download experimental 3D coordinates of 657 with added hydrogens

SODIUM CHANNEL ALPHA SUBUNIT BLOCKER CHEMBL2331043 SODIUM CHANNEL ALPHA SUBUNIT P35498 SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA HOMO SAPIENS ION CHANNEL VGC VG NAANSM (in French)

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