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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
OLANZAPINE

OLANZAPINE


ATC N05AH03

NERVOUS SYSTEM
ANTIPSYCHOTIC
TREATMENT OF SCHIZOPHRENIA
SEROTONIN 5HT-2A (KI=4 NANOMOLAR), 5HT-2C (KI=11 NANOMOLAR), 5HT-6 (KI=11 NANOMOLAR) ANTAGONIST
D(2) DOPAMINE RECEPTOR ANTAGONIST
DOPAMINE D1-4 (KI=11-31 NANOMOLAR)
HISTAMINE H1 (KI=7 NANOMOLAR)
ADRENERGIC ALPHA-1 RECEPTOR (KI=19 NANOMOLAR)
SEROTONIN 5HT-3 (KI=57 NANOMOLAR)
MUSCARINIC M1-5 (KI=32-132 NANOMOLAR)

ORAL INTRAMUSCULAR

Tmax 6 HOUR

VD 1000 LITER

PPB 93 PERCENT

Cl 25 LITER / HOUR

HT 30 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

5-HYDROXYTRYPTAMINE 2A RECEPTOR (5HT-2)
D(2) DOPAMINE RECEPTOR

D2-LIKE DOPAMINE RECEPTOR ANTAGONIST CHEMBL2331075 D2-LIKE DOPAMINE RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTORANSM (in French)

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