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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IRINOTECAN

IRINOTECAN


ATC L01XX19

ANTINEOPLASTIC
TOPOISOMERASE I INHIBITOR
CAMPTOTHECIN DERIVATIVES

INJECTION INTRAVENOUS

Cmax 5.78 MICROMOLAR

VD 376 LITER

PPB 49 PERCENT

Cl 22.3 LITER / HOUR

HT 8 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

DNA TOPOISOMERASE I COMPLEX

PDB 1U65 (ACHE W. CPT-11)

LIGAND CODE = CP0 (link to the list of PDB complexes)

Download experimental 3D coordinates of CP0 with added hydrogens

DNA TOPOISOMERASE I INHIBITOR CHEMBL1781 DNA TOPOISOMERASE I P11387 DNA TOPOISOMERASE 1 HOMO SAPIENS ENZYME ISOMERASEANSM (in French)

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