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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ZAFIRLUKAST

ZAFIRLUKAST


ATC R03DC01

RESPIRATORY SYSTEM
PEPTIDE LEUKOTRIENE RECEPTOR ANTAGONIST (LTRA)
ANTIASTHMATIC

ORAL

Cmax 567 NANOMOLAR

Tmax 3 HOUR

VD 70 LITER

PPB 99 PERCENT

Cl 20 LITER / HOUR

HT 10 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

PEPTIDE LEUKOTRIENE RECEPTOR LTD4
PEPTIDE LEUKOTRIENE RECEPTOR LTE4

PDB 6RZ5 (XFEL CRYSTAL STRUCTURE OF THE HUMAN CYSTEINYL LEUKOTRIENE RECEPTOR 1 IN COMPLEX WITH ZAFIRLUKAST)

LIGAND CODE = ZLK (link to the list of PDB complexes)

Download experimental 3D coordinates of ZLK with added hydrogens

CYSTEINYL LEUKOTRIENE RECEPTOR 1 ANTAGONIST CHEMBL1798 CYSTEINYL LEUKOTRIENE RECEPTOR 1 Q9Y271 CYSTEINYL LEUKOTRIENE RECEPTOR 1 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR LEUKOTRIENE RECEPTORANSM (in French)

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