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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TOPIRAMATE
| TOPIRAMATE | NERVOUS SYSTEM | ORAL | Tmax 2 HOUR F 80 PERCENT VD 45.4 LITER (EQN) PPB 28 PERCENT Cl 1.5 LITER / HOUR HT 21 HOUR SOLUBILITY 9.8 MILLIGRAM / MILLILITER IN WATER | VOLTAGE-DEPENDENT SODIUM CHANNEL GLUTAMATE RECEPTOR CARBONIC ANHYDRASE PDB 3LXE (HUMAN CARBONIC ANHYDRASE I IN COMPLEX WITH TOPIRAMATE) LIGAND CODE = TOR (link to the list of PDB complexes) Download experimental 3D coordinates of TOR with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A more at DrugCentral | EMA | |||
