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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GLIMEPIRIDE

GLIMEPIRIDE


ATC A10BB12
ATC A10BD06
ATC A10BD04

METABOLISM
ANTIDIABETIC
TREATMENT OF TYPE 2 DIABETES MELLITUS
HYPOGLYCEMIC AGENTS
SULFONYLUREAS

ORAL

Cmax 353 NANOMOLAR

Tmax 2.5 HOUR

F 100 PERCENT

VD 8.8 LITER

PPB 95.5 PERCENT

Cl 2.8 LITER / HOUR

HT 5.08 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL

PDB 4YVX (CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH GLIMEPIRIDE)

LIGAND CODE = GMR (link to the list of PDB complexes)

Download experimental 3D coordinates of GMR with added hydrogens

SULFONYLUREA RECEPTOR 2, O60706 ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9 HOMO SAPIENS TRANSPORTER NTPASE ATP BINDING CASSETTE MRPANSM (in French)

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