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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BRIMONIDINE

BRIMONIDINE


ATC D11AX21
ATC S01EA05
ATC S01GA07

SENSORY
ADRENERGIC ALPHA 2 AGONISTS
ANTIHYPERTENSIVE AGENTS

OPHTHALMIC TOPICAL

Cmax 0.102 NANOMOLAR

Tmax 2 HOUR

PPB 29 PERCENT

HT 3 HOUR

SOLUBILITY SOLUBLE IN WATER 34 MILLIGRAM / MILLILITER

ALPHA-2 ADRENERGIC RECEPTOR

PDB 7EJ8 (STRUCTURE OF THE ALPHA2A-ADRENERGIC RECEPTOR GOA SIGNALING COMPLEX BOUND TO BRIMONIDINE)

LIGAND CODE = J59 (link to the list of PDB complexes)

Download experimental 3D coordinates of J59 with added hydrogens

Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B

more at DrugCentral

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