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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ACARBOSE

ACARBOSE


ATC A10BF01
ATC A10BD17

METABOLISM
MEMBRANE-BOUND INTESTINAL ALPHA-GLUCOSIDE HYDROLASE INHIBITOR
HYPOGLYCEMIC AGENTS
DELAYS THE DIGESTION OF INGESTED CARBOHYDRATES
PANCREATIC ALPHA-AMYLASE INHIBITOR

ORAL

Tmax 1 HOUR

F 2 PERCENT

VD 20.8 LITER (65 KILOGRAM)

Cl 8.5 LITER / HOUR (65 KILOGRAM)

HT 2 HOUR

SOLUBILITY SOLUBLE IN WATER

LYSOSOMAL ALPHA-GLUCOSIDASE
PANCREATIC ALPHA-AMYLASE

PDB 5HQA (A GLYCOSIDE HYDROLASE FAMILY 97 ENZYME IN COMPLEX WITH ACARBOSE FROM PSEUDOALTEROMONAS SP. STRAIN K8)

LIGAND CODE = ACR (link to the list of PDB complexes)

Download experimental 3D coordinates of ACR with added hydrogens

MALTASE-GLUCOAMYLASE INHIBITOR CHEMBL2074 MALTASE-GLUCOAMYLASE O43451 MALTASE-GLUCOAMYLASE, INTESTINAL HOMO SAPIENS ENZYME HYDROLASEANSM (in French)

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