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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ZILEUTON

ZILEUTON

ANTIINFLAMMATORY
INHIBITS LEUKOTRIENE SYNTHESIS
5-LIPOXYGENASE INHIBITORS

ORAL

Cmax 21.1 MICROMOLAR

Tmax 1.7 HOUR

VD 78 LITER (65 KILOGRAM)

PPB 93 PERCENT

Cl 27.3 LITER / HOUR (65 KILOGRAM)

HT 2.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

5-LIPOXYGENASE

ARACHIDONATE 5-LIPOXYGENASE INHIBITOR CHEMBL215 ARACHIDONATE 5-LIPOXYGENASE P09917 ARACHIDONATE 5-LIPOXYGENASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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