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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MIRTAZAPINE

MIRTAZAPINE


ATC N06AX11

NERVOUS SYSTEM
ANTIDEPRESSANT
ADRENERGIC ALPHA ANTAGONISTS
HISTAMINE H1 ANTAGONISTS
5-HYDROXYTRYPTAMINE RECEPTOR ANTAGONIST

ORAL

Tmax 2 HOUR

F 50 PERCENT

VD 273 LITER (65 KILOGRAM)

PPB 85 PERCENT

Cl 31.2 LITER / HOUR (65 KILOGRAM)

HT 30 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

ALPHA-2A ADRENERGIC RECEPTOR
5-HYDROXYTRYPTAMINE 2 RECEPTOR
5-HYDROXYTRYPTAMINE 3 RECEPTOR
HISTAMINE H1 RECEPTOR

5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A -- 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C

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