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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LOSARTAN (has an active metabolite)
| LOSARTAN |
CARDIOVASCULAR | ORAL | Tmax 1 HOUR F 33 PERCENT VD 34 LITER PPB 98.7 PERCENT Cl 36 LITER / HOUR HT 2 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | TYPE-1 ANGIOTENSIN II RECEPTOR PDB 5X24 (CRYSTAL STRUCTURE OF CYP2C9 GENETIC VARIANT I359L (*3) IN COMPLEX WITH MULTIPLE LOSARTAN MOLECULES) LIGAND CODE = LSN (link to the list of PDB complexes) Download experimental 3D coordinates of LSN with added hydrogens | Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 more at DrugCentral | EMA | |||
