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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ANAGRELIDE
| ANAGRELIDE | ANTINEOPLASTIC | ORAL | Tmax 1 HOUR F 70 PERCENT HT 1.5 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | CYCLIC AMP PHOSPHODIESTERASE III PDB 7EG0 (CRYO-EM STRUCTURE OF ANAGRELIDE-INDUCED PDE3A-SLFN12 COMPLEX) LIGAND CODE = J33 (link to the list of PDB complexes) Download experimental 3D coordinates of J33 with added hydrogens | cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A more at DrugCentral | EMA | |||
