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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LAMOTRIGINE

LAMOTRIGINE


ATC N03AX09

NERVOUS SYSTEM
ANTICONVULSANT
ANTIEPILEPTIC
PHENYLTRIAZINE
TREATMENT OF BIPOLAR I DISORDER
SODIUM CHANNEL BLOCKER

ORAL

Tmax 1.7 HOUR

F 98 PERCENT

VD 71.5 LITER (65 KILOGRAM)

PPB 55 PERCENT

Cl 2.2 LITER / HOUR (65 KILOGRAM)

HT 25.4 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER (0.17 MILLIGRAM / MILLILITER)

VOLTAGE-SENSITIVE SODIUM CHANNEL

SODIUM CHANNEL ALPHA SUBUNIT BLOCKER CHEMBL2331043 SODIUM CHANNEL ALPHA SUBUNIT P35498 SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA HOMO SAPIENS ION CHANNEL VGC VG NAANSM (in French)

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