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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LAMOTRIGINE
| LAMOTRIGINE | NERVOUS SYSTEM | ORAL | Tmax 1.7 HOUR F 98 PERCENT VD 71.5 LITER (65 KILOGRAM) PPB 55 PERCENT Cl 2.2 LITER / HOUR (65 KILOGRAM) HT 25.4 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER (0.17 MILLIGRAM / MILLILITER) | VOLTAGE-SENSITIVE SODIUM CHANNEL PDB 8THH (CRYO-EM STRUCTURE OF NAV1.7 WITH LTG) LIGAND CODE = IYJ (link to the list of PDB complexes) Download experimental 3D coordinates of IYJ with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A more at DrugCentral | EMA | |||
