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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GABAPENTIN (is an active metabolite)
| GABAPENTIN | NERVOUS SYSTEM | ORAL | Cmax 16.26 MICROMOLAR (600 MILLIGRAM OF GABAPENTIN ENACARBIL) F 75 PERCENT VD 76 LITER PPB 3 PERCENT Cl 7.6 LITER / HOUR HT 5.5 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | VOLTAGE-GATED CALCIUM CHANNEL (PMID26680202) PDB 2COI (CRYSTAL STRUCTURE OF OXIDIZED HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE COMPLEXED WITH GABAPENTIN) LIGAND CODE = GBN (link to the list of PDB complexes) Download experimental 3D coordinates of GBN with added hydrogens | Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 more at DrugCentral | EMA | |||
