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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CLADRIBINE (has an active metabolite)

CLADRIBINE


ATC L01BB04
ATC L04AA40

ANTINEOPLASTIC
IMMUNOSUPPRESSIVE AGENTS
TREATMENT OF HAIRY CELL LEUKEMIA

INJECTION ORAL

VD 292.5 LITER (65 KILOGRAM)

PPB 20 PERCENT

Cl 63.5 LITER / HOUR (65 KILOGRAM)

HT 5.4 HOUR

DEOXYCYTIDINE KINASE

PDB 2ZIA (C4S DCK VARIANT OF DCK IN COMPLEX WITH CLADRIBINE+UDP)

LIGAND CODE = CL9 (link to the list of PDB complexes)

Download experimental 3D coordinates of CL9 with added hydrogens

Unknown

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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