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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMIFOSTINE (has an active metabolite)

AMIFOSTINE


ATC V03AF05

VARIOUS
RADIATION-PROTECTIVE AGENTS
PRODRUG
REDUCTION OF THE CUMULATIVE RENAL TOXICITY OF CISPLATIN AND FOR THE REDUCTION OF THE TOXIC EFFECTS OF RADIATION ON NORMAL ORAL TISSUES
INTESTINAL-TYPE ALKALINE PHOSPHATASE (IAP) IS A MAJOR ISOENZYME INVOLVED IN THE HYDROLYSIS OF AMIFOSTINE (PMID12577238)

INJECTION

Cmax 200 MICROMOLAR

VD 7 LITER

Cl 120 LITER / HOUR

HT 0.13 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

ALKALINE PHOSPHATASE

Unknown

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