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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FINASTERIDE

FINASTERIDE


ATC G04CB01
ATC D11AX10
ATC G04CA51

DERMATOLOGICALS
ANTI-BALDNESS AGENTS
5 ALPHA REDUCTASE INHIBITORS

ORAL

Cmax 99.4 NANOMOLAR

Tmax 1.5 HOUR

F 63 PERCENT

VD 76 LITER

PPB 90 PERCENT

Cl 9.9 LITER / HOUR

HT 6 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

5-ALPHA DEHYDROGENASE

PDB 3G1R (CRYSTAL STRUCTURE OF HUMAN LIVER 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP AND FINASTERIDE. RESOLUTION 1.70 A)

LIGAND CODE = FIT (link to the list of PDB complexes)

Download experimental 3D coordinates of FIT with added hydrogens

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 P18405 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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