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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NEFAZODONE

NEFAZODONE


ATC N06AX06

NERVOUS SYSTEM
ANTIDEPRESSANT
ANALGESICS
SEROTONIN AGENTS
5-HYDROXYTRYPTAMINE 2A RECEPTOR ANTAGONIST

ORAL

Tmax 1 HOUR

F 20 PERCENT

VD 35.4 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 29.2 LITER / HOUR (65 KILOGRAM)

HT 3 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

5-HYDROXYTRYPTAMINE 2A RECEPTOR
SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
ALPHA-1A ADRENERGIC RECEPTOR
ALPHA-1B ADRENERGIC RECEPTOR
SODIUM-DEPENDENT SEROTONIN TRANSPORTER

NOREPINEPHRINE TRANSPORTER INHIBITOR CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

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ChEMBL
BindingDB
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