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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUMAZENIL
| FLUMAZENIL | VARIOUS | INJECTION | Cmax 79 NANOMOLAR VD 65 LITER (65 KILOGRAM) PPB 50 PERCENT Cl 58.5 LITER / HOUR (65 KILOGRAM) HT 1 HOUR SOLUBILITY INSOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR PDB 6D6T (HUMAN GABA-A RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA AND FLUMAZENIL, CONFORMATION B) LIGAND CODE = FYP (link to the list of PDB complexes) Download experimental 3D coordinates of FYP with added hydrogens | Gamma-aminobutyric acid receptor subunit alpha-4 UNIPROT P48169 GABRA4 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 more at DrugCentral | EMA | |||
